Bioconductor 3.7 release and the DelayedArray framework

Today marks the release of Bioconductor 3.7 (official announcement). Congratulations to the hundreds of developers who have collectively developed more than 1500 software packages, not to mention the annotation, experiment data, and workflow packages. A huge thank you to the core team for the incredible work they do, especially around release time! Much of my recent development work on Bioconductor has been leveraging and extending the DelayedArray framework developed by Hervé Pagès (Bioconductor Core Team).

Analysing Illumina Infinium 450k methylation arrays

Dr Alicia Oshlack, head of Bioinformatics at the Murdoch Children’s Research Institute and formerly of WEHI Bioinformatics, gave today’s Bioinformatics seminar at WEHI. Her topic was “Analysing Human Infinium 450k Methylation Arrays”, in particular the normalisation and quality control issues associated with them. I’ve fleshed out the notes I made during the seminar, below. Alicia credited Jovana Maksimovic and Livinia Gordon (members of her lab) with most of the work she was to present today.